ABOUT THE Marijuana PLANT

Your body has it’s own cannabinoid system, with two receptors called CB1 and CB2 and two ligands called anadamine and 2-AG, plus regulatory enzymes.  This system has a role in pain, appetite, mood, memory, inflammation, insulin sensitivity, metabolism, etc. The CB1 receptors are all throughout the brain/nervous system, gastrointestinal tract, reproductive system, adrenals, heart, lung, and bladder tissues. CB2 receptors are primarily found in the immune system. The marijuana plant has >100 phytocannabinoids, which are chemicals that mimic our own system. The glandular structure of the plant, called the trichome, produces resin  phytocannabinoids including terpenes, which give the plant its characteristic smell.

THC – aka Delta-9-tetrahydrocannabinol
Works by activating mostly CB1, but also CB2 receptors and others not mentioned. Therefore, medicinally it can be used for its psychotropic features, anti-inflammatory, anti-cancer, analgesic, muscle relaxant/anti-spasmotic, and antioxidant with neuroprotective properties.

CBD- aka Cannabidiol
Non-psychotropic, used as a “entourage compound” to reduce side effects of THC. The list of potential uses includes anti-anxiety or anti-psychotic, anti-emetic via modulation of central feeding behavior, anti-arthritic, anti-inflammatory, neuroprotection, and immunomodulation with additional anti-fungal and antibacterial properties. While additional research is needed, initial reports are that CBD is nontoxic to non-transformed cells.

CBC- Cannabichromene
Third most prevalent phytocannabinoid, it has properties beneficial as anti-inflammatory, sedative, analgesic, antifungal and antibacterial agent. Animal studies also suggest use as antidepressant.

CBG – aka Cannabigerol
This chemical weakly activates CB1 and CB2, but also antagonizes 5HT and allows GABA neurotransmitters to maintain function in the brain. Strong anti-inflammatory properties suggest use in IBD like Crohns Disease and colon cancers, use with glaucoma, and as a powerful antibacterial.

CBN – aka Cannabinol
Found in aged cannabis, is a product of THC breakdown with less CB1 and great CB2 affinity, therefore with less nervous system and psychotropic potential, but influence over the immune system, as anti-inflammatory and antibacterial.

THCA – aka Tetrahydrocannabolic acid
Found in raw, undried cannabis, Non-activated form of THC, with animal studies ongoing to show neuroprotective effects and benefit with nausea and vomiting.

THCV – aka Tetrahydrocannabivarin
It can activate CB2 and block CB1, which allows for antioxidant and possible antipsychotic and anticonvulsant properties. In studies it shows promise to delay progression of Parkinsons symptoms.

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1

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2

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3

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